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Primary Cells

Human Brain Microvascular Endothelial Cells

  • For research use only

Cat No.

ABC-TC3524
Product Type

Nervous Cells
Cell Type

Endothelial
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Brain
Disease

Normal
Storage

Liquid Nitrogen

Utilize Human Brain Microvascular Endothelial Cells to model BBB permeability, neurovascular signaling, and CNS-targeted drug delivery mechanisms.

Product Image
  • Brightfield micrograph of Human Brain Microvascular Endothelial Cells, showing adherent growth, 4X magnification.
  • Human Brain Microvascular Endothelial Cells
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Home | Primary Cells | Human Primary Cells | Nervous System Primary Cells | Human Brain Microvascular Endothelial Cells

Description

Human Brain Microvascular Endothelial Cells (HBMECs) are isolated from the human brain tissues. Brain Microvascular Endothelial Cells (BMECs) form the interface between circulating blood and neural tissue, maintaining the blood-brain barrier (BBB) and regulating the CNS (central nervous system) homeostasis. Endothelial cells (ECs) are flat with a central, elongated nucleus at the microscopic level. Studies have found that compounds such as glucose, amino acids and exogenous drugs can enter brain tissue through special transport proteins expressed in BMECs, including transferrin receptor, insulin-like growth factor receptor, and angiotensin receptor. These cells also express tight junction proteins like claudin-5, occludin, and ZO-1 that form the structural basis of the BBB’s selective permeability. Brain microvascular endothelial cells play a critical role in the protection and maintenance of the brain, where endothelial cells in the brain are integral to forming the selective permeability of the blood-brain barrier.

Product Code

Human Brain Microvascular Endothelial Cells, HBMECs, Cerebral Microvascular Endothelial Cells, Brain MVECs Human, Human BBB Endothelial Cells
Species

Human
Cat.No

ABC-TC3524
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Endothelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Brain
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Nervous Cells
Key Features

-Backed by AcceGen advanced technology
-Ship cryopreserved cells in dry ice
-Quality-tested for accurate results
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Brain Microvascular Endothelial Cells (HBMECs) can be used to study the mechanism of pathogens (such as bacteria and viruses) penetrating the BBB and to evaluate the delivery efficiency of drugs to the central nervous system. In the study of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease, HBMECs are used to analyze the association between vascular dysfunction and pathological development.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Lu X, Tang L, Wu Y, et al. Metabolically aberrant extracellular mitochondria induce oxidative endotheliopathy in traumatic brain injury. Blood Advances. 2025;9(9):2079-2090. doi:10.1182/bloodadvances.2024015296

Frequently Asked Questions

  • What are the primary research applications of Human Brain Microvascular Endothelial Cells?

    These cells are commonly used in studies of the blood-brain barrier, neuroinflammation, and drug transport across the brain endothelium.

  • What are the recommended culture conditions for Human Brain Microvascular Endothelial Cells?

    These cells should be cultured in a specialized endothelial growth medium, under standard cell culture conditions (37°C, 5% CO2).

  • What functional assays can be used with Human Brain Microvascular Endothelial Cells?

    Functional assays for Human Brain Microvascular Endothelial Cells include permeability assays, transendothelial electrical resistance (TEER) measurements, and migration assays. These assays are used to study the barrier properties and dynamics of these cells.

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