Human Breast Cancer Cells

Description

Human Breast Tumor Cancer Cells are derived from malignant breast tissue obtained through surgical resection or biopsy of human patients. They are typically obtained from female patients aged 30-70 years. These cells originate from the epithelial layer of mammary ducts or lobules, with the most common histological subtypes being invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) . Upon isolation, they exhibit characteristic tumorigenic morphology including irregular cell shape, loss of polarity, and formation of disorganized clusters rather than structured acini. Genetically, these cells often harbor mutations in tumor suppressor genes such as TP53 and BRCA1/2, and show amplification of oncogenes like HER2 (ERBB2). They express epithelial markers including cytokeratins (CK7, CK8/18) and breast cancer-associated markers such as estrogen receptor (ER), progesterone receptor (PR), and HER2. Their growth pattern is anchorage-independent. These cells demonstrate aggressive proliferative capacity combined with apoptosis resistance, which significantly contributes to their metastatic potential in vivo..