Human Brown Adipocytes

Description

Human Brown Adipocytes (HBAs) are mature thermogenic cells derived from stromal vascular fractions of human adipose tissue or differentiated from precursor cells. They are characterized by multilocular lipid droplets and high mitochondrial density with robust UCP1 expression, enabling non-shivering thermogenesis through mitochondrial uncoupling. HBAs secrete active batokines such as VEGF-A, FGF21, and IL-6, impacting systemic metabolism and vascular homeostasis. In vitro, they respond to norepinephrine or cold-mimetic compounds by upregulating thermogenic genes (UCP1, CIDEA, PGC1α) and increasing oxygen consumption rate (OCR). These features make them an excellent human cell model for metabolic, pharmacological, and endocrine studies.

Application

• For research use only.

• Human Brown Adipocytes (HBAs) are widely used in metabolic and drug screening assays: they model thermogenic response by measuring changes in OCR and gene expression in response to norepinephrine, β‑agonists, or cold mimetics. They also serve in batokine studies—tracking secreted factors like VEGF-A and IL-6—and in screening anti-obesity or metabolic modulators targeting mitochondrial function and browning pathways. Additionally, HBAs support research into mitochondrial bioenergetics and signaling interactions between adipose and vascular or immune systems.