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Human cKIT (V559D_Y823D) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human cKIT (V559D_Y823D) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0056C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human cKIT (V559D_Y823D) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. cKIT (V559D_Y823D) mutant cell line is generated by lentiviral transduction of the human cKIT gene carrying two oncogenic mutations: V559D in the juxtamembrane domain and Y823D in the activation loop.
Target
The V559D mutation causes ligand-independent dimerization and activation of cKIT, while Y823D enhances downstream kinase activity, driving strong proliferative and survival signals. This dual mutation model is relevant for studying acquired resistance to tyrosine kinase inhibitors in cancer. AcceGen offers stable expression models for detailed signal transduction research. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The cKIT (V559D_Y823D) BAF3 Cell Line supports research into primary and secondary cKIT mutations, structure-function analysis, and resistance profiling. It is suitable for compound screening, kinase profiling, and therapeutic strategy development.

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