For research use only
| Cat No. | ABC-X0302C |
| Product Type | Overexpression Stable Cell Lines |
| Cell Type | Fibroblast |
| Species | Human |
| Host Cell | NIH/3T3 |
| Source Organ | Embryo |
| Disease | Normal |
| Storage | Liquid Nitrogen |
CLIP1_LTK (L590M) NIH/3T3 Cell Line supports detailed studies of CLIP1_LTK mutations and effect on cancer cell proliferation and targeted drug response.
Human CLIP1_LTK (L590M) NIH/3T3 Cell Line is engineered to express the CLIP1_LTK fusion protein with an L590M mutation in NIH/3T3 cells. This model allows for the study of gain-of-function effects and pathway alterations induced by this specific mutation in fibroblast cells.
Target
The L590M mutation occurs within the LTK tyrosine kinase domain and is hypothesized to enhance kinase activity or alter inhibitor binding. It is relevant to targeted cancer therapy research and understanding mutation-specific signaling profiles.
AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.
| Species | Human |
| Cat.No | ABC-X0302C |
| Product Category | Transfected Stable Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Fibroblast |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 °C, 5% CO2 |
| Source Organ | Embryo |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Overexpression Stable Cell Lines |
| Host Cell | NIH/3T3 |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
This cell line provides a valuable platform for studying CLIP1_LTK-driven tumorigenesis, screening small-molecule inhibitors, and analyzing downstream signaling cascades activated by the L590M variant.