Colonic epithelium cover the colonic mucosal surface and maintain the gut homeostasis by harboring the commensal bacteria in the outer mucus layer. Most colonic epithelial cells are absorptive colonocytes distributed in the crypt top, composed of specilised lineages including secretory goblet and enteroendocrine cells (EECs). They not only coordinate gut absorptive and secretory process, but also control mucosal immunity by presenting antigens to T cells. Dysregulation of the colonic homeostasis is often associated with intestinal inflammation, which underpins various intestinal disorders including bacterial infection, inflammatory bowel disease (IBD) and colonic cancer. Why choose Human Colonic Epithelial Cells from AcceGen? AcceGen human colonic epithelial cells are isolated from human colon tissue. Cells at P1 are cryopreserved immediately after isolation. Each vial contains more than 5×10^5 cells in 1 ml volume. Cells are characterized positive for CK18 and CK19 by immunofluorescence. All cell lots are tested negative for HIV-1, HBV, HCV and other pathogens. Human colonic epithelial cells are quality tested to further culture for 10 population doublings following AcceGen’s recommended protocols.
All cells test negative for mycoplasma, bacteria, yeast, and fungi.
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For research use only Human colonic epithelial cells provide an ideal cell culture model for studying the physiology and pathophysiology of epithelial cells, including: -Colonic signalling pathways associated with colonic inflammation and carcinogenesis such as TGF-β and Gpr109a receptor -Drug and Zinc oxide nanoparticles safety evaluation -Genetic expression profiling -Host-microorganism symbiosis and their instructive role in mucosal immunity -Electrocyte transportation of colon epithelium and their potential role in disease
-Backed by AcceGen advanced technology -Cryopreserved for highest viability and plating efficiency -Quality-tested for accurate results -Expert teams to provide timely support and assist best experimental outcomes
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