Human Cortical Neurons (HCN) are primary cells isolated from the healthy cerebral cortex of humans. Distinguished into two major categories—neurons and glia. Morphologically, differentiated HCN cells display branched structures with mature neuronal features. these cells express neuronal markers including β3-Tuj, MAP2, and VGLUT1/2. Their dysfunction is implicated in neurological disorders, particularly epilepsy and Alzheimer’s disease, via altered Ih current dynamics and dendritic excitability.
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