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Human Dermal Fibroblasts, Adult

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Cells are isolated from adult abdominal dermal explants and provided either cryopreserved or in a variety of plated formats. Dermal Fibroblasts are available from donors with and without Type 2 diabetes.
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Home | Primary Cells | Human Primary Cells | Others | Human Dermal Fibroblasts, Adult
Product Code

HDF-a
Species

Human
Cat.No

ABC-TC3029
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Others
Size/Quantity

1 vial
Cell Type

Fibroblast
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Dermal
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Dermal Cells

Description

Human Dermal Fibroblasts, AdultHuman Dermal Fibroblasts, Adult are primary cells isolated from the dermal layer of human skin. These cells exhibit an adherent culture properties, forming confluent monolayers with a dense, overlapping growth pattern. Functionally, HDFa synthesize extracellular matrix components like collagen and elastin, orchestrate wound healing through fibronectin-mediated migration, and interact with epidermal cells during tissue repair and hair follicle development. Human Dermal Fibroblasts demonstrate mesenchymal stem cell-like properties, expressing surface markers CD73, CD90, and CD105. They serve as cellular substrates for induced pluripotent stem cell (iPSC) reprogramming using the Yamanaka transcription factors (Oct3/4, Sox2, Klf4, c-Myc).

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Citation

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Application

  • HDFa serve as a versatile model system for investigating various facets of cell physiology and have been prominently featured in numerous research works, especially within the realms of skin biology and reprogramming studies. These fibroblasts find application in diverse areas such as pathogen response, skin aging, wound healing, gene delivery, and skin-related disorders like scleroderma. Their utility extends to research involving ECM protein analysis, collagen metabolism, cosmetics, skin therapy, and model development, encompassing an array of multidisciplinary research avenues.

Frequently Asked Questions

  • What are Human Dermal Fibroblasts (HDFs)?

    Human Dermal Fibroblasts (HDFs) are cells derived from the dermis layer of human skin. They play a crucial role in the synthesis and remodeling of the extracellular matrix and are essential for wound healing and skin maintenance.

  • How do I ensure the optimal growth and health of HDFs in culture?

    To ensure optimal growth and health of HDFs, monitor cell confluency regularly and passage cells when they reach 80-90% confluency. Avoid over-confluency to prevent cell differentiation and senescence. Handle cells gently to avoid mechanical stress and maintain consistent culture conditions.

  • What are the morphological characteristics of HDFs in culture?

    In culture, HDFs typically exhibit a spindle-shaped, elongated morphology with prominent nuclei. They tend to grow in a monolayer with characteristic fibroblastic extensions. The cells should appear uniform and healthy without signs of stress or contamination.

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