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Primary Cells

Human Dopaminergic Neurons

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Human dopaminergic neuronal cells are isolated from fetal brain tissue obtained from agencies authorized to procure and distribute tissues for research. Dopaminergic neuronal cells are selected in tyrosine free medium supplemented with a mixture of growth factors. Actively growing population of cells are tested for tyrosine hydroxylase (TH) expression by immunocytochemistry. HDaNCs cells are provided […]
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Home | Primary Cells | Human Primary Cells | Nervous System Primary Cells | Human Dopaminergic Neurons
Product Code

HDaNCs
Species

Human
Cat.No

ABC-TC5463
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Neuron
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Nervous Cells
Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results

Description

Human Dopaminergic Neuron Cells
Human Dopaminergic Neurons primarily isolated from midbrain precursors, particularly the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA), during development. These neurons exhibit a characteristic morphology with small, round or oval somata, long and highly branched axons, and extensive dendritic arbors. Dopaminergic neurons synthesize and release dopamine, modulating motor control, reward processing, cognition, and emotion via D1- and D2-type receptor signaling. Their tonic and phasic firing patterns regulate nigrostriatal (movement) and mesocorticolimbic (motivation) pathways. Dysfunction or degeneration of SNc dopaminergic neurons underlies Parkinson’s disease (PD), characterized by Lewy body accumulation and motor deficits. Mesolimbic dopamine hyperactivity is implicated in schizophrenia and addiction.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

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Application

  • Human Dopaminergic Neurons can be used to study the development, electrophysiological characteristics and neural circuit regulation mechanisms of the dopamine system, especially the neural basis of motor control, reward behavior and cognitive function. These cells can also be used for neurotoxicity assessment, such as the effects of environmental toxins (MPTP, 6-OHDA) or gene mutations on neuronal survival.

Frequently Asked Questions

  • What are human dopaminergic neurons, and what is their primary function?

    Human dopaminergic neurons are neurons that produce and release dopamine, a neurotransmitter crucial for motor control, reward, and motivation. They play a key role in the central nervous system.

  • How are human dopaminergic neurons typically obtained and cultured for research purposes?

    They are typically derived from stem cells, such as iPSCs or embryonic stem cells, through differentiation protocols. They are cultured in specialized media that support their growth and functionality

  • What are the main applications of Human Dopaminergic Neurons in scientific research?

    They are used to study neurodegenerative diseases like Parkinson’s, for drug screening, and to understand dopamine-related disorders. Additionally, they assist in developing and testing new therapies.

  • What are the key characteristics when culturing Human Dopaminergic Neurons?

    Key characteristics include the expression of markers like TH (tyrosine hydroxylase), DAT (dopamine transporter), and their ability to produce and release dopamine

  • What are the main challenges of culturing and experimenting with Human Dopaminergic Neurons?

    Challenges include maintaining cell viability and dopaminergic properties, preventing contamination, and replicating the complex in vivo environment of the brain in vitro.

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