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Transfected Stable Cell Lines

Human EML4 ALK (F1174L) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0013C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

The EML4-ALK (F1174L) BAF3 Cell Line supports research on resistance to ALK inhibitors and mechanisms of ALK-driven transformation in cancer.

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  • Human EML4 ALK (F1174L) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human EML4 ALK (F1174L) BAF3 Cell Line

Description

The EML4 ALK (F1174L) BAF3 Cell Line is constructed by lentiviral-mediated stable integration of human EML4-ALK fusion carrying the F1174L activating mutation into BAF3 cells. This mutation occurs within the ALK kinase domain and contributes to increased oncogenicity and reduced inhibitor binding. Stable clones are maintained under antibiotic selection and confirmed by qRT-PCR.
Target
EML4-ALK is a constitutively active fusion protein in non-small cell lung cancer (NSCLC). The F1174L mutation enhances kinase activity and induces resistance to ALK inhibitors such as crizotinib. This model is suitable for studying ALK-driven oncogenesis and resistance mechanisms. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0013C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • The EML4 ALK (F1174L) BAF3 Cell Line is ideal for drug resistance screening, functional validation of ALK inhibitors, and investigation of downstream signaling in ALK-mutant NSCLC. It supports the development of next-generation therapeutics overcoming ALK resistance mutations.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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