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Human EML4 ALK (F1174L) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human EML4 ALK (F1174L) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0013C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

The EML4 ALK (F1174L) BAF3 Cell Line is constructed by lentiviral-mediated stable integration of human EML4-ALK fusion carrying the F1174L activating mutation into BAF3 cells. This mutation occurs within the ALK kinase domain and contributes to increased oncogenicity and reduced inhibitor binding. Stable clones are maintained under antibiotic selection and confirmed by qRT-PCR.
Target
EML4-ALK is a constitutively active fusion protein in non-small cell lung cancer (NSCLC). The F1174L mutation enhances kinase activity and induces resistance to ALK inhibitors such as crizotinib. This model is suitable for studying ALK-driven oncogenesis and resistance mechanisms. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The EML4 ALK (F1174L) BAF3 Cell Line is ideal for drug resistance screening, functional validation of ALK inhibitors, and investigation of downstream signaling in ALK-mutant NSCLC. It supports the development of next-generation therapeutics overcoming ALK resistance mutations.

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