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Human EML4_ALK (F1174C_G1202R) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human EML4_ALK (F1174C_G1202R) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0288C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human EML4_ALK (F1174C_G1202R) BAF3 Cell Line is a murine Ba/F3-derived model expressing the EML4-ALK fusion gene with F1174C and G1202R mutations. The model is established by lentiviral delivery and maintained below passage 20. Gene expression is verified by qRT-PCR.
Target
EML4-ALK fusions drive oncogenesis via constitutive ALK kinase activity. F1174C and G1202R variants promote enhanced signaling and drug resistance. This double mutant is of high relevance in relapsed ALK-positive cancers. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This dual-mutant fusion model enables exploration of compound mutation effects in ALK signaling and development of advanced targeted inhibitors.

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