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Transfected Stable Cell Lines

Human EML4_ALK (R1275Q) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0093C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

EML4-ALK (R1275Q) BAF3 Cell Line offers a tool for investigating ALK mutation–related signaling and testing ALK inhibitor efficacy in vitro.

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  • Human EML4_ALK (R1275Q) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human EML4_ALK (R1275Q) BAF3 Cell Line

Description

Human EML4_ALK (R1275Q) BAF3 Cell Line is a stable murine pro-B cell model derived from Ba/F3 cells, engineered via lentiviral transduction to express the EML4-ALK fusion gene with a clinically significant R1275Q mutation. Transgene expression is verified by qRT-PCR, and the cells are maintained at low passage numbers (<P20). Target The EML4-ALK fusion gene is a potent oncogenic driver in non-small cell lung cancer. The R1275Q mutation enhances kinase activity and may alter responsiveness to ALK inhibitors. ALK fusions activate MAPK, PI3K-AKT, and STAT3 signaling cascades, promoting cell survival and transformation. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers' research needs.

Species

Human
Cat.No

ABC-X0093C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • This model enables functional characterization of EML4-ALK fusion activity and resistance mechanisms to ALK-targeted therapies, serving as a preclinical tool for drug screening and biomarker validation.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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