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Human EML4_ALK (R1275Q) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human EML4_ALK (R1275Q) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0093C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human EML4_ALK (R1275Q) BAF3 Cell Line is a stable murine pro-B cell model derived from Ba/F3 cells, engineered via lentiviral transduction to express the EML4-ALK fusion gene with a clinically significant R1275Q mutation. Transgene expression is verified by qRT-PCR, and the cells are maintained at low passage numbers (<P20). Target The EML4-ALK fusion gene is a potent oncogenic driver in non-small cell lung cancer. The R1275Q mutation enhances kinase activity and may alter responsiveness to ALK inhibitors. ALK fusions activate MAPK, PI3K-AKT, and STAT3 signaling cascades, promoting cell survival and transformation. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers' research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This model enables functional characterization of EML4-ALK fusion activity and resistance mechanisms to ALK-targeted therapies, serving as a preclinical tool for drug screening and biomarker validation.

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