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Human ERBB2 (R678Q) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human ERBB2 (R678Q) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0005C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human ERBB2 (R678Q) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. ERBB2 (R678Q) BAF3 mutant cell line is generated by stable integration of exogenous human ERBB2 gene harboring the R678Q point mutation into Ba/F3 host cells using our optimized transduction of lentiviral vectors.
Target
The ERBB2 (HER2) gene encodes a transmembrane receptor tyrosine kinase critical for cell signaling cascades that control proliferation and survival. The R678Q mutation lies in the juxtamembrane domain and has been associated with enhanced dimerization and receptor activation independent of ligand binding. This mutation contributes to oncogenesis by triggering sustained downstream signaling, notably through MAPK and PI3K/AKT pathways, and has been reported in lung adenocarcinoma and other solid tumors. AcceGen offers generation of stable mutation-specific or overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

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Application

  • For research use only

  • The ERBB2 (R678Q) BAF3 Cell Line serves as a powerful tool to investigate HER2-juxtamembrane mutation-driven oncogenic mechanisms and therapeutic interventions. This model enables studies of dimerization-mediated activation, IL-3-independent growth, and resistance to tyrosine kinase inhibitors. It is utilized for high-throughput screening of HER2-targeted therapies and evaluation of combination treatment strategies.

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