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Transfected Stable Cell Lines

Human ERBB2 (V773M) NIH/3T3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human ERBB2 (V773M) NIH/3T3 Cell Line
Species

Human
Cat.No

ABC-X0315C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Fibroblast
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Embryo
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

NIH/3T3

Description

Human ERBB2 (V773M) NIH/3T3 Overexpression Cell Line is a genetically engineered model derived from NIH/3T3 mouse fibroblast cells based on customers’ requirement. The cell line stably expresses the human ERBB2 (V773M) mutant via lentiviral-mediated integration. Engineered cells are maintained under low passage conditions (<P20), and expression is validated at the gene level using qRT-PCR. Target ERBB2, also known as HER2, is a member of the EGFR family of receptor tyrosine kinases. The V773M mutation resides in the kinase domain and has been implicated in aberrant signaling in various cancers, including breast and gastric cancer. This alteration can enhance ligand-independent dimerization and downstream PI3K/AKT and MAPK pathway activation. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers' research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This cell line is a useful model for evaluating oncogenic signaling driven by ERBB2 (V773M) and assessing sensitivity to HER2-targeted agents, including small-molecule inhibitors and monoclonal antibodies. It enables mechanistic studies and drug discovery related to HER2-driven malignancies.

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