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Transfected Stable Cell Lines

Human ERBB2 (V842I) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human ERBB2 (V842I) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0001C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human ERBB2 (V842I) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. ERBB2 (V842I) BAF3 mutant cell line is generated by stable integration of exogenous human ERBB2 (V842I) gene into Ba/F3 host cells using our optimized transduction of lentiviral vectors. The expression cassette contains the full-length ERBB2 open reading frame harboring the clinically relevant V842I point mutation.
Target
The ERBB2 (HER2) gene encodes a transmembrane receptor tyrosine kinase belonging to the EGFR family. The V842I mutation, located within the kinase domain, leads to constitutive activation of downstream oncogenic pathways including PI3K/AKT and MAPK. This gain-of-function mutation has been implicated in tumorigenesis and drug resistance in multiple cancer types such as lung adenocarcinoma and breast carcinoma. ERBB2 (V842I) serves as a potential therapeutic target due to its role in promoting cell proliferation and survival independent of ligand binding. AcceGen offers generation of stable mutation-specific or overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

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Application

  • For research use only

  • The ERBB2 (V842I) BAF3 Cell Line serves as a powerful tool to investigate ERBB2-driven oncogenic mechanisms and therapeutic interventions. This model enables mechanistic studies of kinase domain mutations, IL-3-independent proliferation, and drug resistance in hematopoietic and solid tumor models. It is utilized for high-throughput screening of ERBB2-targeted inhibitors, including irreversible kinase inhibitors and antibody-based therapeutics.

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