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Transfected Stable Cell Lines

Human Estrogen Receptor Luciferase Reporter Cell Line-T47D

  • For research use only

Cat No.

ABC-RC0012
Product Type

Reporter Stable Cell Line
Species

Human
Host Cell

T47D
Storage

Liquid Nitrogen

Human Estrogen Receptor Luciferase Reporter Cell Line-T47D provides a model for ER signaling, breast cancer biology, and drug discovery applications.

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  • Human Estrogen Receptor Luciferase Reporter Cell Line-T47D
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Home | Transfected Stable Cell Lines | Reporter Stable Cell Lines | Human Estrogen Receptor Luciferase Reporter Cell Line-T47D

Description

The Human Estrogen Receptor Luciferase Reporter Cell Line-T47D is a reporter stable cell line derived from the human T47D breast cancer cell line. The cells stably express a firefly luciferase reporter gene under the control of an estrogen response element (ERE), enabling detection of estrogen receptor (ER)-mediated transcriptional activity through a measurable luminescent signal. This model provides a cell-based system for investigating ER signaling and evaluating cellular responses to estrogenic or anti-estrogenic stimuli. Estrogen-responsive reporter activity should be confirmed under the relevant experimental conditions using product-specific quality control data.

Species

Human
Cat.No

ABC-RC0012
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Reporter Stable Cell Line
Host Cell

T47D
Stock

Custom

Application

  • The Human Estrogen Receptor Luciferase Reporter Cell Line-T47D can be used for estrogen receptor signaling research, estrogenic and anti-estrogenic activity assessment, compound screening, and breast cancer research. Treatment with estrogenic stimuli can activate ER-mediated transcription and increase reporter activity, while ER antagonists can inhibit estrogen-induced luciferase responses. The reporter system can therefore support evaluation of compounds that modulate ER signaling and investigation of cellular responses to hormonal or pharmacological stimuli. Published studies have used T47D-based estrogen-responsive luciferase reporter systems to detect estrogen receptor agonists and antagonists and to screen compounds affecting estrogen-dependent signaling.

Area of Interest

The Human Estrogen Receptor Luciferase Reporter Cell Line-T47D supports research in estrogen receptor signaling, estrogen-responsive gene regulation, breast cancer biology, endocrine signaling, and drug discovery. The ERE-driven luciferase reporter provides a quantitative readout of ER transcriptional activity, allowing researchers to investigate how estrogenic compounds, anti-estrogenic compounds, or other experimental interventions influence ER-mediated signaling in a human breast cancer cell context. This model can also support screening and characterization of compounds that modulate estrogen-dependent transcriptional responses.

Workflow Stages

Cell Recovery (Recover and expand the T47D estrogen receptor reporter cells under recommended culture conditions.) → Cell Culture (Maintain the cells under appropriate culture conditions and monitor cell morphology and growth.) → Experimental Treatment (Expose the reporter cells to estrogenic compounds, ER antagonists, or other experimental treatments according to the research objective.) → ER Signaling Activation (Allow experimental stimuli to modulate estrogen receptor signaling and ERE-dependent transcriptional activity.) → Luciferase Detection (Measure firefly luciferase activity using a compatible luminescence detection system.) → Response Analysis (Compare reporter activity between treated and control groups to evaluate changes in ER-mediated transcriptional responses.) → Compound Evaluation (Characterize estrogenic or anti-estrogenic activity and investigate compounds that modulate ER signaling.)

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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