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Transfected Stable Cell Lines

Human ETV6 FGFR4 (C477A) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0021C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

This BAF3 cell line with ETV6-FGFR4 (C477A) mutation provides a model for studying altered kinase activity and targeted therapy development.

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  • Human ETV6 FGFR4 (C477A) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human ETV6 FGFR4 (C477A) BAF3 Cell Line

Description

The ETV6 FGFR4 (C477A) BAF3 Cell Line is a genetically engineered model derived from murine BAF3 cells. It stably expresses the human ETV6-FGFR4 fusion gene harboring the C477A mutation, introduced via lentiviral transduction. This mutation resides in the FGFR4 kinase domain, disrupting cysteine-mediated disulfide bond formation and enhancing constitutive activation.
Target
ETV6-FGFR4 fusion promotes ligand-independent FGFR4 activation and is implicated in hematologic malignancies. The C477A mutation enhances kinase activity and drives oncogenic signaling pathways such as MAPK and PI3K/AKT. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0021C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • This model facilitates drug screening of FGFR4 inhibitors, exploration of resistance mechanisms, and mechanistic studies of FGFR-driven transformation in hematological cancers.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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