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Human ETV6 FGFR4 (C477A) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human ETV6 FGFR4 (C477A) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0021C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

The ETV6 FGFR4 (C477A) BAF3 Cell Line is a genetically engineered model derived from murine BAF3 cells. It stably expresses the human ETV6-FGFR4 fusion gene harboring the C477A mutation, introduced via lentiviral transduction. This mutation resides in the FGFR4 kinase domain, disrupting cysteine-mediated disulfide bond formation and enhancing constitutive activation.
Target
ETV6-FGFR4 fusion promotes ligand-independent FGFR4 activation and is implicated in hematologic malignancies. The C477A mutation enhances kinase activity and drives oncogenic signaling pathways such as MAPK and PI3K/AKT. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This model facilitates drug screening of FGFR4 inhibitors, exploration of resistance mechanisms, and mechanistic studies of FGFR-driven transformation in hematological cancers.

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