1
Discover top-quality products tailored for scientific and medical research. Request a personalized quote today
to enhance your projects.
Species | Human |
Cat.No | ABC-X0025C |
Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
Product Category | Transfected Stable Cell Lines |
Size/Quantity | 1 vial |
Cell Type | Lymphocytes |
Shipping Info | Dry Ice |
Growth Conditions | 37 °C, 5% CO2 |
Source Organ | Lymphatic |
Disease | Normal |
Biosafety Level | 1 |
Storage | Liquid Nitrogen |
Product Type | Overexpression Stable Cell Lines |
Host Cell | BAF3 |
The ETV6 FGFR4 (C477S) BAF3 Cell Line is engineered by lentiviral transduction of human ETV6-FGFR4 fusion carrying the C477S mutation into BAF3 cells. This alteration disrupts native disulfide bonding, mimicking ligand-independent receptor dimerization and activation.
Target
FGFR4 mutations at C477 are known to stabilize kinase activation. The ETV6-FGFR4 (C477S) fusion promotes oncogenic signaling, contributing to cell survival and proliferation in hematologic disorders. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.
For research use only