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Transfected Stable Cell Lines

Human ETV6 FGFR4 (C477S) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0025C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

This engineered BAF3 cell line expresses ETV6-FGFR4 (C477S) to investigate oncogenic kinase signaling and response to therapeutic inhibitors.

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  • Human ETV6 FGFR4 (C477S) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human ETV6 FGFR4 (C477S) BAF3 Cell Line

Description

The ETV6 FGFR4 (C477S) BAF3 Cell Line is engineered by lentiviral transduction of human ETV6-FGFR4 fusion carrying the C477S mutation into BAF3 cells. This alteration disrupts native disulfide bonding, mimicking ligand-independent receptor dimerization and activation.
Target
FGFR4 mutations at C477 are known to stabilize kinase activation. The ETV6-FGFR4 (C477S) fusion promotes oncogenic signaling, contributing to cell survival and proliferation in hematologic disorders. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0025C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • This cell line enables assessment of FGFR4-targeted inhibitors and downstream oncogenic signaling, offering a reliable model for precision therapy research.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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