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Transfected Stable Cell Lines

Human ETV6 LCK BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human ETV6 LCK BAF3 Cell Line
Species

Human
Cat.No

ABC-X0039C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

The ETV6 LCK BAF3 Cell Line expresses a chimeric gene combining the transcriptional regulator ETV6 and the SRC-family kinase LCK. Stable integration via lentiviral vector enables constitutive kinase activation in BAF3 cells. Clonal selection and validation are performed via gene expression analysis.
Target
ETV6-LCK fusion leads to constitutive LCK activation, contributing to leukemogenesis by activating downstream STAT5 and PI3K signaling. This rare fusion has been reported in T-ALL. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This model aids in dissecting LCK-driven signaling in leukemia and assessing targeted inhibitors in T-cell malignancies.

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