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Transfected Stable Cell Lines

Human ETV6_ARAF BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0060C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

Human ETV6-ARAF BAF3 Cell Line is designed to model aberrant MAPK signaling and supports evaluation of kinase inhibitors in preclinical studies.

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  • Human ETV6_ARAF BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human ETV6_ARAF BAF3 Cell Line

Description

The Human ETV6_ARAF BAF3 Cell Line is a genetically engineered model derived from the murine pro-B cell line BAF3 based on customers’ requirement. This overexpression cell line is generated by stable integration of exogenous human ETV6_ARAF fusion gene into BAF3 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
The ETV6_ARAF fusion encodes a chimeric oncoprotein combining the transcription factor ETV6 and ARAF, a member of the RAF kinase family. This fusion results in constitutive MAPK signaling activation, promoting cellular proliferation and oncogenesis. It has been identified in hematologic malignancies, including myeloid leukemia. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0060C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • The Human ETV6_ARAF BAF3 Cell Line is valuable for studying ARAF-driven leukemogenic pathways and for screening RAF/MEK/ERK inhibitors. It supports mechanistic exploration of MAPK pathway dysregulation and resistance in hematologic cancers.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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