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Transfected Stable Cell Lines

Human ETV6_ARAF BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human ETV6_ARAF BAF3 Cell Line
Species

Human
Cat.No

ABC-X0060C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

The Human ETV6_ARAF BAF3 Cell Line is a genetically engineered model derived from the murine pro-B cell line BAF3 based on customers’ requirement. This overexpression cell line is generated by stable integration of exogenous human ETV6_ARAF fusion gene into BAF3 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
The ETV6_ARAF fusion encodes a chimeric oncoprotein combining the transcription factor ETV6 and ARAF, a member of the RAF kinase family. This fusion results in constitutive MAPK signaling activation, promoting cellular proliferation and oncogenesis. It has been identified in hematologic malignancies, including myeloid leukemia. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The Human ETV6_ARAF BAF3 Cell Line is valuable for studying ARAF-driven leukemogenic pathways and for screening RAF/MEK/ERK inhibitors. It supports mechanistic exploration of MAPK pathway dysregulation and resistance in hematologic cancers.

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