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Transfected Stable Cell Lines

Human ETV6_BTK (C481G) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0043C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

ETV6-BTK (C481G) BAF3 Cell Line is designed for investigating BTK inhibitor resistance and targeted therapeutic screening in leukemia models.

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  • Human ETV6_BTK (C481G) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human ETV6_BTK (C481G) BAF3 Cell Line

Description

The ETV6 BTK (C481G) BAF3 Cell Line stably expresses the ETV6-BTK fusion protein carrying the C481G mutation, introduced via lentiviral transduction. This mutation affects BTK’s covalent inhibitor binding site, conferring resistance to ibrutinib. Edited clones are validated at the molecular level.
Target
ETV6-BTK fusions promote BTK-dependent survival signaling. The C481G mutation is associated with drug resistance in B-cell malignancies, impairing irreversible inhibitor efficacy. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0043C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Ideal for studying BTK-driven lymphoid malignancies and for evaluating next-generation non-covalent BTK inhibitors.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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