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Human ETV6_BTK (C481G) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human ETV6_BTK (C481G) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0043C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

The ETV6 BTK (C481G) BAF3 Cell Line stably expresses the ETV6-BTK fusion protein carrying the C481G mutation, introduced via lentiviral transduction. This mutation affects BTK’s covalent inhibitor binding site, conferring resistance to ibrutinib. Edited clones are validated at the molecular level.
Target
ETV6-BTK fusions promote BTK-dependent survival signaling. The C481G mutation is associated with drug resistance in B-cell malignancies, impairing irreversible inhibitor efficacy. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • Ideal for studying BTK-driven lymphoid malignancies and for evaluating next-generation non-covalent BTK inhibitors.

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