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Transfected Stable Cell Lines

Human FGFR2 (C382R) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0088C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocyte
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

The FGFR2 (C382R) BAF3 cell line is a genetically engineered model suitable for studying the FGFR2 signaling pathway and tumor treatment interventions.

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  • Human FGFR2 (C382R) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human FGFR2 (C382R) BAF3 Cell Line

Description

Human FGFR2 (C382R) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. FGFR2 (C382R) BAF3 mutant cell line is generated by stable integration of exogenous human FGFR2 gene harboring the C382R mutation into Ba/F3 host cells using our optimized transduction of lentiviral vectors.
Target
FGFR2 encodes a receptor tyrosine kinase essential for development and cellular homeostasis. The C382R mutation occurs in the extracellular domain and induces ligand-independent receptor dimerization and constitutive activation, promoting tumorigenic signaling. It has been identified in intrahepatic cholangiocarcinoma and endometrial carcinoma. AcceGen offers generation of stable mutant cell lines with defined oncogenic alterations. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0088C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • The FGFR2 (C382R) BAF3 Cell Line serves as a powerful tool to investigate aberrant FGFR2 signaling and therapeutic intervention. This model supports IL-3-independent proliferation, allowing assessment of FGFR-targeted therapies and resistance mechanisms. It is utilized in pathway dissection and personalized drug screening in oncology research.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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