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Human FGFR2 (K659Q) BICC1 BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human FGFR2 (K659Q) BICC1 BAF3 Cell Line
Species

Human
Cat.No

ABC-X0069C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human FGFR2 (K659Q) BICC1 BAF3 Cell Line is a lentivirally transduced Ba/F3 model that stably expresses the FGFR2-BICC1 fusion with a K659Q point mutation. Cells are cultured under low passage conditions (<P20), and gene overexpression is validated using qRT-PCR techniques. Target The FGFR2 K659Q mutation within the FGFR2-BICC1 fusion enhances kinase activity and contributes to oncogenesis via activation of RAS/MAPK and PI3K/AKT signaling. It is frequently associated with intrahepatic cholangiocarcinoma and other FGFR2 fusion-positive tumors. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers' research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This model enables in-depth investigation of FGFR2 mutation-driven signaling and resistance to tyrosine kinase inhibitors. It is suited for preclinical testing of FGFR2-targeted drugs and understanding oncogenic driver dependency.

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