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Human FGFR3 (N540K) TACC3 BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human FGFR3 (N540K) TACC3 BAF3 Cell Line
Species

Human
Cat.No

ABC-X0017C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

The FGFR3 (N540K) TACC3 BAF3 Cell Line is established by stable lentiviral expression of the FGFR3-TACC3 fusion with an additional N540K mutation in BAF3 cells. The N540K substitution is a known oncogenic driver, promoting constitutive kinase activity. Edited cells are validated via qRT-PCR and maintained at low passages.
Target
FGFR3-TACC3 fusions are found in bladder cancer and glioblastoma. The N540K mutation enhances autophosphorylation and activation of downstream signaling. This model serves as a platform to study FGFR3 oncogenicity and response to inhibitors targeting the altered kinase domain. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The FGFR3 (N540K) TACC3 BAF3 Cell Line is used for evaluating FGFR-targeted therapies, investigating resistance mechanisms, and modeling oncogenic signaling in FGFR3-driven cancers.

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