Human Fibroblast-Like Synoviocytes Osteoarthritis, Adult (FLS-OA) are primary cells isolated from human synovial tissues. These cells typically cryopreserved at the earliest passage and have a proliferative capacity of ≥5 population doublings. FLS-OA constitute 75-80% of the synovial intimal lining and are classified as type B synoviocytes. Functionally, they play a critical role in maintaining joint homeostasis by contributing to synovial fluid formation and regulating chondrocyte nourishment. Under pathological conditions such as rheumatoid arthritis and osteoarthritis, they adopt an aggressive phenotype, characterized by increased secretion of pro-inflammatory cytokines and matrix metalloproteinases that contribute to cartilage degradation. These cells express characteristic markers, including Cadherin-11, VCAM-1, CD90 and CD55. 
Inquiring Human Fibroblast-Like Synoviocyte Osteo Arthritis, Adult
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