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Human FLT3 (K663Q) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human FLT3 (K663Q) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0022C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human FLT3 (K663Q) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. FLT3 (K663Q) BAF3 mutant cell line is generated by stable integration of exogenous human FLT3 gene harboring the K663Q point mutation into Ba/F3 host cells using our optimized transduction of lentiviral vectors.
Target
FLT3 is a class III receptor tyrosine kinase that plays a crucial role in early hematopoiesis. The K663Q mutation occurs in the juxtamembrane region and is reported to promote constitutive dimerization and kinase activation. Activating mutations in FLT3 are strongly associated with acute myeloid leukemia (AML) and confer poor prognosis. AcceGen offers generation of stable overexpression and mutation-specific cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The FLT3 (K663Q) BAF3 Cell Line serves as a powerful tool to investigate FLT3 mutation-mediated leukemogenesis and targeted drug sensitivity. This model enables mechanistic studies of IL-3-independent proliferation, JAK/STAT and MAPK pathway activation, and FLT3 inhibitor resistance. It is utilized for high-throughput screening of next-generation FLT3-targeted therapies in AML research.

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