Human Gingival Fibroblasts

Description

Human Gingival Fibroblasts (HGFs) are isolated from healthy human gingival tissue. Morphologically, these cells are spindle-shaped or star-shaped and grow adherently when cultured in vitro. They play a crucial role in synthesizing extracellular matrix components such as collagen fibers and elastic fibers, and participate in the repair and regeneration of gingival tissue. HGFs also play a key role in sustaining the inflammatory response by interacting with pathogens and their component lipopolysaccharide (LPS) in periodontal disease. Under inflammatory conditions, HGFs can secrete various cytokines and chemokines, such as IL-6 and IL-8, which amplify the immune response and contribute to periodontal tissue destruction. Additionally, their ability to modulate immune cell activity makes them crucial players in both wound healing and chronic inflammatory processes like periodontitis. Overall, gingival fibroblasts are essential for maintaining the structural integrity and biological function of gingiva by coordinating extracellular matrix turnover, immune regulation, and tissue homeostasis.

Application

• Human Gingival Fibroblasts can be used as an in vitro cell model to study the pathogenesis of periodontal disease, especially to explore the molecular mechanism of fibroblast dysfunction in diseases such as gingival recession and periodontitis. These cells can also be used to construct bioactive scaffolds to promote the regeneration of gingival defects.