Human Head and Neck Cancer Peripheral Blood Mononuclear Cells

Description

Human Head and Neck Cancer Peripheral Blood Mononuclear Cells (PBMCs) are immune cells isolated from the peripheral blood of patients with head and neck squamous cell carcinoma (HNSCC). These PBMCs contain a representative population of immune cells (T cells, B cells, NK cells, and monocytes) that reflect the unique immunosuppressive tumor microenvironment characteristic of HNSCC. Morphologically, PBMCs are typically small, round cells. They play a key role in antitumor immune responses T cells mediate cellular immunity, B cells produce antibodies, and NK cells execute innate cytotoxicity, whereas monocytes differentiate into tumor-associated macrophages (TAMs) that modulate the tumor microenvironment. The cells exhibit typical HNSCC-associated immune alterations including increased regulatory T cells (Tregs), exhausted CD8⁺ T cell populations (expressing PD-1, TIM-3, LAG-3), and tumor-associated macrophages. These PBMCs enable detailed analysis of T cell subsets in head and neck cancer, investigation of B cell role in head and neck cancer, comprehensive PBMC phenotyping head and neck cancer, and assessment of autoimmune markers in head and neck cancer.