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Primary Cells

Human Hepatitis B Virus (HBV) Peripheral Blood Mononuclear Cells

  • For research use only

Cat No.

ABC-TC4323
Product Type

Diseased Human Peripheral Blood Mononuclear Cells
Cell Type

Mononuclear Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Hepatitis B Virus
Storage

Liquid Nitrogen

Human HBV PBMCs from chronic hepatitis B patients, include T/B/NK cells and monocytes, ideal for studying viral immunity and immune dysfunction.

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  • Human Hepatitis B Virus (HBV) Peripheral Blood Mononuclear Cells
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Home | Primary Cells | Human Primary Cells | PBMCs | Human Hepatitis B Virus (HBV) Peripheral Blood Mononuclear Cells

Description

Human Hepatitis B Virus (HBV) Peripheral Blood Mononuclear Cells (PBMCs) are isolated from individuals with HBV infection, a hepatotropic DNA virus causing acute and chronic liver disease. They consist of lymphocytes (T cells, B cells, NK cells) and monocytes that play dual roles in viral persistence and host defense. These PBMCs exhibit profound immune dysregulation characteristic of HBV pathogenesis. Chronic infection leads to CD8⁺ T cell exhaustion (via PD-1/CTLA-4 upregulation), Tregs-mediated suppression, and impaired antigen presentation – all facilitating viral persistence. HBV antigens (HBsAg, HBcAg) directly modulate PBMC function, while viral DNA integration may establish extrahepatic reservoirs. The resulting Th1/Th2 imbalance and NK cell dysfunction contribute to progressive liver damage, including fibrosis and hepatocellular carcinoma development. Importantly, HBV manipulates PBMC cytokine networks (reduced IFN-γ, elevated IL-10) to evade immune clearance while promoting chronic inflammation. These PBMCs are widely used to investigate immune dysregulation and viral persistence, profile cytokine and cellular immune responses, identify inflammation-related biomarkers, and support the development and evaluation of therapeutic strategies for hepatitis B.

Species

Human
Cat.No

ABC-TC4323
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Mononuclear Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Hepatitis B Virus
Storage

Liquid Nitrogen
Product Type

Diseased Human Peripheral Blood Mononuclear Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Hepatitis B Virus (HBV) Peripheral Blood Mononuclear Cells can be used to study immune response in HBV infection. For example, they can be applied to analyze HBV-specific T cell functions (such as cytotoxicity and cytokine secretion), B cell antibody production ability, and the antigen presentation function of monocytes/dendritic cells, thereby revealing the molecular mechanisms of immune clearance or immune tolerance.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Quality Control Report

  • Test Item
  • Flow Cytometry
  • Flow Cytometry
  • Result
  • Hu-FLS (NC) HBV-PBMC

    Flow cytometry plot of Hu-FLS (NC), showing CD3 expression to be 0.053%.Flow cytometry plot of HBV-PBMC, showing CD4 and CD8 expression to be 36.5% and 61.9% respectively.

    The percentage of CD4 and CD8 expression in T cell subsets were detected by flow cytometry to be 36.5% and 61.9%, respectively, consistent with normal T cell distribution in peripheral blood.

  • Hu-FLS (NC) HBV-PBMC

    Flow cytometry quadrant plot of Hu-FLS, showing CD14 and CD33 expression.Flow cytometry quadrant plot of HBV-PBMC, showing CD14 and CD33 expression to identify different immunological subsets.

    Monocytes strongly express CD14 and CD33 (Q2), dendritic cells strongly express CD33 and weakly express CD14 (Q1), granulocytes weakly express CD14 and CD33 (Q4), consistent with the PBMC phenotype.

Frequently Asked Questions

  • What are Human Hepatitis B Virus (HBV) Peripheral Blood Mononuclear Cells (PBMCs)?

    Human Hepatitis B Virus (HBV) Peripheral Blood Mononuclear Cells (PBMCs) are a subset of white blood cells obtained from the whole blood of individuals with confirmed Hepatitis B status. These cells include various types of lymphocytes (T cells, B cells, NK cells) and monocytes, which play a crucial role in the body’s immune response against diseases.

  • How to isolate Human HBV PBMCs from whole blood?

    Human HBV PBMCs are isolated from whole blood using density gradient centrifugation, a process that separates blood components based on their density. Additionally, red blood cell lysis is performed to remove unwanted cells, ensuring a purified population of PBMCs.

  • Are Human HBV PBMCs useful for research?

    Yes. Human HBV PBMCs are useful for research because they can serve as a reservoir for HBV, potentially leading to chronic infection. They are valuable tools for studying the immune response to HBV, developing diagnostic methods, and creating therapeutic strategies to combat the virus and related immune system disorders.

  • What makes AcceGen’s Human HBV PBMCs a preferred choice for researchers?

    AcceGen’s Human HBV PBMCs are produced in a sterile environment by professional operators, ensuring high-quality standards. They employ advanced cryopreservation techniques to maintain high cell viability after thawing. These factors make AcceGen’s PBMCs reliable and effective for research, diagnostics, and therapeutic development related to HBV and the immune system.

  • What are the key applications of Human HBV PBMCs in scientific research?

    Human HBV PBMCs are used in various research applications, including studying the immune response to HBV, investigating the mechanisms of chronic HBV infection, developing new diagnostic tools, and creating and testing potential therapies for HBV and related immune system diseases.

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