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Transfected Stable Cell Lines

Human HRAS (G12C) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human HRAS (G12C) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0031C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human HRAS (G12C) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. HRAS (G12C) BAF3 mutant cell line is generated by stable integration of exogenous human HRAS gene harboring the G12C mutation into Ba/F3 host cells using our optimized transduction of lentiviral vectors.
Target
HRAS is a membrane-bound GTPase regulating cell proliferation and survival through the RAS/MAPK pathway. The G12C mutation results in constitutive activation of HRAS, leading to dysregulated downstream signaling. This alteration has emerged as a therapeutic target in precision oncology, particularly in solid tumors such as lung and pancreatic cancers. AcceGen offers generation of stable overexpression and point-mutant cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The HRAS (G12C) BAF3 Cell Line is a robust system for evaluating mutant HRAS function, oncogenic transformation, and drug sensitivity. This model is ideal for screening covalent inhibitors, studying adaptive resistance, and exploring the role of HRAS signaling in hematologic and solid malignancies.

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