Human HRAS (G12C) BAF3 Cell Line

Description

Human HRAS (G12C) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. HRAS (G12C) BAF3 mutant cell line is generated by stable integration of exogenous human HRAS gene harboring the G12C mutation into Ba/F3 host cells using our optimized transduction of lentiviral vectors.
Target
HRAS is a membrane-bound GTPase regulating cell proliferation and survival through the RAS/MAPK pathway. The G12C mutation results in constitutive activation of HRAS, leading to dysregulated downstream signaling. This alteration has emerged as a therapeutic target in precision oncology, particularly in solid tumors such as lung and pancreatic cancers. AcceGen offers generation of stable overexpression and point-mutant cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.