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Transfected Stable Cell Lines

Human IL7Ra_CRLF2 BAF3 Cell Line

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  • 60
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human IL7Ra_CRLF2 BAF3 Cell Line
Species

Human
Cat.No

ABC-X0370C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human IL7Ra_CRLF2 BAF3 Cell Line is a genetically engineered model derived from selected murine pro-B Ba/F3 parental cell line based on customers’ requirement. IL7Ra_CRLF2 BAF3 overexpression cell line is generated by stable integration of exogenous human IL7Rα and CRLF2 genes into BAF3 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
IL7Rα and CRLF2 form a functional heterodimeric receptor that activates JAK/STAT signaling upon ligand binding. Aberrant overexpression of the IL7Ra–CRLF2 axis is implicated in high-risk B-cell acute lymphoblastic leukemia (B-ALL). AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The IL7Ra_CRLF2 BAF3 Overexpression Cell Line serves as a key model for studying leukemogenic signaling, drug resistance, and preclinical testing of JAK pathway inhibitors in B-ALL.

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