Human iPSC-Derived Sebocytes

Description

Sebocytes are epithelial cells specialized in sebum production. They are located in the sebaceous gland, in association with a hair follicle, building the pilo-sebaceous unit. These glands are found all over the body, with 400 to 900 glands/cm², except on the palms of the hands and soles of the feet. A young sebocyte is a tiny cell, the older they get the biggest they are, as they produce and accumulate lipids until their membrane breaks down and release the sebum. This process is called holocrine secretion. Sebaceous glands continuously release sebum, a mixture of lipids and cell debris, via a channel along the hair. A lot of different functions are attributed to sebum : antimicrobial, antioxidant, transport of pheromones, thermoregulation, hydration, and suppleness of the skin. Sebocyte functions are still a topic of intense research. AcceGen’s sebocytes, derived from human iPSC and provided at low passage, are available in a 2-million-cell format. Human iPSC-derived sebocytes are provided as KRT7+ precursors and can be amplified twice.

Application

• For research use only