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Human Kidney Endothelial Cells

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Species

Human

Cat.No

ABC-TC147W

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial

Cell Type

Endothelial Cell

Shipping Info

Dry Ice

Growth Conditions

37 °C, 5% CO2

Source Organ

Kidney

Disease

Normal

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Kidney Cells

Description

Human Kidney Endothelial Cells are primary cells isolated from human kidney tissue, specifically from the glomerular microvascular endothelium. These cells maintain endothelial characteristics, including the expression of CD31, VE-cadherin, and von Willebrand factor (vWF), and exhibit functional responses to shear stress and inflammatory stimuli. They play a crucial role in regulating glomerular filtration and maintaining the blood–urine barrier. In vitro, these cells form monolayers with tight junctions and are used to model endothelial dysfunction in kidney diseases such as diabetic nephropathy and glomerulonephritis. They are also employed in drug screening, vascular biology research, and the development of kidney-on-a-chip models. Their ability to mimic native endothelial behavior makes them invaluable for studying renal vascular physiology and pathology.

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Application

  • For research use only.

  • Human Kidney Endothelial Cells are utilized to study glomerular endothelial function, endothelial–mesangial cell interactions, and the effects of shear stress on endothelial behavior. They are employed in drug screening assays to assess nephrotoxicity and in the development of kidney-on-a-chip models to simulate renal microvascular dynamics. These cells are also used to investigate the pathophysiology of kidney diseases, including diabetic nephropathy and glomerulonephritis, by modeling endothelial dysfunction and barrier integrity. Their application extends to regenerative medicine, where they contribute to the development of bioengineered kidney tissues and vascularized organoid systems.

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