Human Kidney Endothelial Cells

Description

Human Kidney Endothelial Cells are primary cells isolated from human kidney tissue, specifically from the glomerular microvascular endothelium. These cells maintain endothelial characteristics, including the expression of CD31, VE-cadherin, and von Willebrand factor (vWF), and exhibit functional responses to shear stress and inflammatory stimuli. They play a crucial role in regulating glomerular filtration and maintaining the blood–urine barrier. In vitro, these cells form monolayers with tight junctions and are used to model endothelial dysfunction in kidney diseases such as diabetic nephropathy and glomerulonephritis. They are also employed in drug screening, vascular biology research, and the development of kidney-on-a-chip models. Their ability to mimic native endothelial behavior makes them invaluable for studying renal vascular physiology and pathology.