Human KIF5B_RET (E732K) BAF3 Cell Line

Description

Human KIF5B_RET (E732K) BAF3 Overexpression Cell Line is a genetically engineered model derived from murine BAF3 pro-B cells based on customers’ requirement. The KIF5B-RET fusion gene carrying the E732K mutation is stably introduced into BAF3 cells via lentiviral vector delivery. Clonal validation is performed by qRT-PCR, and cells are kept at low passage numbers (<P20). Target The E732K mutation in the KIF5B-RET fusion alters the RET kinase domain conformation, potentially enhancing oncogenic activity or mediating drug resistance. It is relevant in therapeutic studies targeting RET-altered cancers. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.