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Human KIF5B_RET (I788N) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human KIF5B_RET (I788N) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0059C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

The Human KIF5B_RET (I788N) BAF3 Cell Line is a genetically engineered model derived from the murine pro-B cell line BAF3 based on customers’ requirement. This overexpression cell line is generated by stable integration of exogenous human KIF5B_RET (I788N) fusion gene into BAF3 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
The KIF5B_RET (I788N) fusion combines the motor protein KIF5B with the receptor tyrosine kinase RET, harboring the I788N mutation. This genetic alteration confers constitutive kinase activation, leading to aberrant cell growth and survival through MAPK and PI3K/AKT pathways. RET fusion events are recurrent in lung adenocarcinomas and thyroid cancers. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The Human KIF5B_RET (I788N) BAF3 Cell Line provides a relevant model for dissecting RET fusion-driven oncogenesis and for evaluating selective RET inhibitors. This system supports drug screening, resistance mechanism analysis, and RET-targeted therapeutic development in solid tumor contexts.

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