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Transfected Stable Cell Lines

Human KIF5B_RET (I788N) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human KIF5B_RET (I788N) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0349C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human KIF5B_RET (I788N) BAF3 Overexpression Cell Line is a genetically engineered model derived from murine BAF3 pro-B cells based on customers’ requirement. The cell line stably expresses the human KIF5B-RET fusion gene carrying an I788N mutation, integrated via lentiviral vector transduction. Gene expression is validated by qRT-PCR and cells are maintained at low passage numbers (<P20). Target The KIF5B-RET fusion protein is an oncogenic driver identified in non-small cell lung cancer (NSCLC). The I788N mutation enhances RET kinase activity and may impact therapeutic responses to RET inhibitors. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This cell line expresses the KIF5B-RET fusion harboring the I788N mutation, relevant in RET-rearranged cancers such as NSCLC. It allows exploration of RET-mediated oncogenic signaling, resistance to RET inhibitors, and functional consequences of specific point mutations within the fusion construct. This model is suitable for preclinical screening of RET-targeted therapies and studying downstream pathways such as RAS-ERK and PI3K-AKT.

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