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Human KIF5B_RET (I788N) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human KIF5B_RET (I788N) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0349C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human KIF5B_RET (I788N) BAF3 Overexpression Cell Line is a genetically engineered model derived from murine BAF3 pro-B cells based on customers’ requirement. The cell line stably expresses the human KIF5B-RET fusion gene carrying an I788N mutation, integrated via lentiviral vector transduction. Gene expression is validated by qRT-PCR and cells are maintained at low passage numbers (

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This cell line expresses the KIF5B-RET fusion harboring the I788N mutation, relevant in RET-rearranged cancers such as NSCLC. It allows exploration of RET-mediated oncogenic signaling, resistance to RET inhibitors, and functional consequences of specific point mutations within the fusion construct. This model is suitable for preclinical screening of RET-targeted therapies and studying downstream pathways such as RAS-ERK and PI3K-AKT.

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