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Transfected Stable Cell Lines

Human KIF5B_RET (L865V) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0351C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

Human KIF5B_RET (L865V) BAF3 Cell Line, KIF5B, BAF3, Overexpression Stable Cell Lines, Transfected Stable Cell Lines

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  • Human KIF5B_RET (L865V) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human KIF5B_RET (L865V) BAF3 Cell Line

Description

Human KIF5B_RET (L865V) BAF3 Overexpression Cell Line is a genetically engineered model derived from murine BAF3 pro-B cells based on customers’ requirement. The cell line is constructed via stable integration of human KIF5B-RET fusion carrying a L865V mutation using optimized lentiviral transduction. The overexpressing clone is verified by qRT-PCR and maintained at low passage numbers (<P20). Target KIF5B-RET fusion proteins drive oncogenic signaling in multiple cancers. The L865V mutation lies within the RET kinase domain, and is associated with altered kinase activity or resistance to selective RET inhibitors. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0351C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Designed for modeling the L865V point mutation in the KIF5B-RET fusion protein, this cell line facilitates analysis of mutation-driven signaling changes, oncogenic activity, and drug resistance. It provides a robust system for evaluating RET inhibitor efficacy, mapping phosphorylation dynamics, and testing mutation-specific responses to kinase-targeted compounds in controlled hematopoietic cell settings.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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