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Human KIF5B_RET (V738A) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human KIF5B_RET (V738A) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0070C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human KIF5B_RET (V738A) BAF3 Cell Line is a murine Ba/F3 cell model engineered to express the KIF5B-RET fusion with a V738A mutation. Lentiviral vectors are used for stable integration, and cells are validated by qRT-PCR under passage numbers <P20. Target The KIF5B-RET fusion is an oncogenic driver identified in non-small cell lung cancer (NSCLC), and the V738A mutation further enhances RET kinase activity. The fusion protein promotes persistent MAPK and PI3K/AKT signaling, driving proliferation and survival in tumor cells. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers' research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This overexpression model is optimal for studying RET fusion oncogenicity and drug responses. It supports development of RET inhibitors and evaluation of resistance mutations in RET-driven NSCLC.

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