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Human KIF5B_RET (V738A) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human KIF5B_RET (V738A) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0390C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human KIF5B_RET (V738A) BAF3 Cell Line is a genetically engineered model derived from selected murine pro-B Ba/F3 parental cell line based on customers’ requirement. KIF5B_RET (V738A) BAF3 overexpression cell line is generated by stable integration of an exogenous human KIF5B-RET fusion gene with a V738A mutation into BAF3 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
KIF5B-RET gene fusion results in ligand-independent RET signaling. The V738A mutation is located within the RET kinase domain and may influence conformation or drug sensitivity. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The KIF5B_RET (V738A) BAF3 Overexpression Cell Line provides a tool for functional assessment of RET fusion variants and compound sensitivity profiling in RET-altered malignancies.

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