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Human KIF5B_RET (Y806C) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human KIF5B_RET (Y806C) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0350C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human KIF5B_RET (Y806C) BAF3 Overexpression Cell Line is a genetically engineered model derived from murine BAF3 pro-B cells based on customers’ requirement. This cell line stably expresses the human KIF5B-RET fusion gene with a Y806C mutation, delivered through lentiviral vector transduction. Gene expression is validated by qRT-PCR and the clone is maintained at low passage numbers (<P20). Target The KIF5B-RET fusion is an oncogenic rearrangement found in lung adenocarcinoma and thyroid carcinoma. The Y806C mutation alters the kinase domain, potentially impacting RET inhibitor sensitivity and downstream oncogenic signaling. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This model expresses the Y806C-mutant form of the KIF5B-RET fusion, which may alter kinase activity or drug binding in RET-driven cancers. It supports in-depth studies of RET oncogenic potential, kinase domain mutations, and resistance mechanisms against selective RET inhibitors. The cell line is ideal for high-throughput drug screening and dissecting structure-function relationships in RET signaling.

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