Human Liver Cancer Peripheral Blood Mononuclear Cells

Description

Human Liver Cancer Peripheral Blood Mononuclear Cells (PBMCs) are isolated from hepatocellular carcinoma (HCC) patients and comprise lymphocytes (T cells, B cells, NK cells) and monocytes, which critically regulate antitumor immunity. In HCC, cytotoxic CD8⁺ T cells and NK cells mediate tumor cell lysis, while immunosuppressive regulatory T cells (Tregs) and tumor-associated macrophages (TAMs)—derived from monocytes—promote immune evasion and tumor progression. PBMCs in HCC often exhibit functional exhaustion (e. g., impaired NK cytotoxicity, T cell dysfunction) and expansion of immunosuppressive subsets, contributing to a permissive tumor microenvironment. These cells serve as a valuable model for studying HCC-related immune dysregulation, biomarker discovery, and immunotherapeutic strategies targeting immune checkpoint pathways or TAM polarization. These PBMCs provide a critical platform for evaluating adaptive immunity in liver cancer, conducting comprehensive PBMC profiling liver cancer, and understanding the overall hepatocellular carcinoma immune response.