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Primary Cells

Human Mobilized Peripheral Blood Mononuclear Cells

  • BSL

    1

  • 137
These Peripheral Blood Mononuclear Cells are collected using the COBE Spectra apheresis machine (>90% of the cells are Mononuclear Cells). These PBMCs products have been depleted of red blood cells and platelets.
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Home | Primary Cells | Human Primary Cells | PBMCs | Human Mobilized Peripheral Blood Mononuclear Cells
Species

Human
Cat.No

ABC-TC3900
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Mononuclear Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Diseased Human Peripheral Blood Mononuclear Cells

Description

Human Mobilized Peripheral Blood Mononuclear Cells (PBMC) are derived from bone marrow hematopoietic stem cells (HSCs), which undergo hematopoietic differentiation to form myeloid and lymphoid progenitor cells, and eventually develop into a heterogeneous population including lymphocytes (T cells, B cells, NK cells), monocytes, and a small number of dendritic cells. Peripheral blood mobilized from bone marrow via cytokine stimulation (e.g., G-CSF).Cells are mainly mononuclear with round to oval nuclei; typically grow in suspension in vitro.Express typical lineage markers such as CD3 (T cells), CD19 (B cells), CD56 (NK cells), CD14 (monocytes).PBMCs are the core of immune response: T cells participate in antigen-specific killing and immune regulation, B cells secrete antibodies, NK cells mediate the clearance of nonspecific tumor/virus-infected cells, and monocytes perform antigen presentation and phagocytosis after differentiation.

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Citation

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Application

  • Human Mobilized Peripheral Blood Mononuclear Cells Human Mobilized Peripheral Blood Mononuclear Cells (PBMCs) can be used to explore immune regulatory mechanisms, hematopoietic differentiation processes, and immune responses to infectious diseases (such as HIV and HBV). They can also be used to evaluate the in vitro effects of immunomodulatory drugs, vaccine efficacy, and immunotherapies such as CAR-T and NK cell therapy. In addition, they can be applied for high-throughput drug screening to detect the immunotoxicity or efficacy of compounds.

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