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Human Motor Neurons (ALS Patient derived iPSC)

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Home | Stem Cells | Induced Pluripotent Stem Cells (iPSCs) | Human Motor Neurons (ALS Patient derived iPSC)
Species

Human
Cat.No

ABC-SC200Y
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Stem Cells
Size/Quantity

1 vial
Cell Type

Neuron
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Ventral Horns
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Human Induced Pluripotent Stem Cells derived

Description

These human iPSC-derived spinal motor neurons are fully differentiated, non-dividing, and exhibit characteristic neuronal morphology with long axonal projections. Derived from reprogrammed dermal fibroblasts or PBMCs using Sendai virus and the Yamanaka factors (OCT4, SOX2, KLF4, c-MYC), the cells show a normal karyotype and express key motor neuron markers including HB9 (MNX1), ISL1, and ChAT. Electrophysiological analysis confirms mature spiking and spontaneous activity. Cells are supplied at low passage and validated by immunocytochemistry to ensure phenotypic identity, purity, and functionality, making them ideal for studying motor neuron development and degeneration in a physiologically relevant context.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

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Application

  • For research use only

  • These motor neurons, differentiated from human induced pluripotent stem cells (iPSCs), originate from either healthy donors or patients with ALS. They serve as physiologically relevant models for studying neurodegenerative disorders such as ALS and spinal muscular atrophy (SMA). Applications include patient-specific disease modeling, compound screening, neurotoxicity testing, and investigations into motor neuron development and function. They provide a robust platform for translational neuroscience and drug discovery research.

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