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Human NASH Peripheral Blood Mononuclear Cells

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Nonalcoholic steatohepatitis (NASH) is liver inflammation and damage caused by a buildup of fat in the liver. Clinical data may include: Medication (current and historical), Disease severity, Fatty infiltration levels
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Home | Primary Cells | Human Primary Cells | PBMCs | Human NASH Peripheral Blood Mononuclear Cells
Species

Human
Cat.No

ABC-TC4340
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Mononuclear Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Non-Alcoholic Steatohepatitis
Storage

Liquid Nitrogen
Product Type

Diseased Human Peripheral Blood Mononuclear Cells

Description

Human NASH Peripheral Blood Mononuclear Cells are immune cells isolated from the peripheral blood of patients with non-alcoholic Steatohepatitis (NASH), a progressive form of non-alcoholic fatty liver disease. PBMCs primarily consist of lymphocytes (T cells, B cells, NK cells) and monocytes. They play a critical role in both systemic and hepatic inflammation, a hallmark of NASH. PBMCs contribute to disease progression through the secretion of pro-inflammatory cytokines (e.g., TNF-α, IL-6), immune cell infiltration into the liver, and activation of fibrogenic signaling pathways.

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Citation

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Application

  • Human NASH Peripheral Blood Mononuclear Cells can be used to explore disease-specific immune dysregulation mechanisms, including abnormal secretion of pro-inflammatory cytokines (such as TNF-α, IL-1β), T cell dysfunction, and differentiation of monocytes to macrophages, which are key processes that promote liver inflammation and fibrosis. They can be used for in vitro drug screening, identification of new biomarkers, and development of immunomodulatory therapies.

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