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Human NCOA4_RET BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human NCOA4_RET BAF3 Cell Line
Species

Human
Cat.No

ABC-X0403C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human NCOA4_RET BAF3 Cell Line is a genetically engineered murine pro-B cell line stably expressing the human NCOA4_RET fusion gene. The Ba/F3 cell line is an interleukin-3 (IL-3)–dependent cell line that becomes IL-3–independent upon expression of oncogenic tyrosine kinases, making it an ideal system to study the transforming ability of NCOA4_RET fusion.
Target
NCOA4_RET is a gene fusion involving nuclear receptor coactivator 4 (NCOA4) and RET (REarranged during Transfection), observed in thyroid and lung cancers. RET fusions lead to constitutive RET kinase activation, promoting downstream oncogenic signaling. The NCOA4_RET fusion provides a model to investigate RET-driven tumorigenesis and targeted inhibition.
AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This cell line serves as a model for investigating RET fusion–driven oncogenic signaling and preclinical assessment of RET inhibitors in hematopoietic cellular contexts.

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