Human Non-Pigment Ciliary Epithelial Cells

Description

Human Non Pigment Ciliary Epithelial Cells (HNPCEpiC) are primary epithelial cells isolated from the non-pigmented layer of the human ciliary body. These cells line the inner surface of the ciliary processes and play a central role in aqueous humor secretion and the maintenance of the blood–aqueous barrier, forming tight-junction monolayers under culture conditions. They exhibit characteristic polygonal, cobblestone morphology and express epithelial markers such as cytokeratin 18/19. Functionally, HNPCEpiCs maintain transepithelial resistance and facilitate directional ion and fluid transport, mediated by enzymes and channels including Na⁺/K⁺ ATPase and TRPP2. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.