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Human NRAS (G12A) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human NRAS (G12A) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0041C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human NRAS (G12A) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. NRAS (G12A) BAF3 mutant cell line is generated by stable integration of exogenous human NRAS gene harboring the G12A mutation into Ba/F3 host cells using our optimized transduction of lentiviral vectors.
Target
NRAS is a small GTPase that regulates signal transduction through the MAPK and PI3K pathways. The G12A mutation impairs GTP hydrolysis and maintains NRAS in an active, GTP-bound state, contributing to constitutive downstream signaling and oncogenesis. This mutation is recurrent in melanoma and hematologic malignancies. AcceGen offers custom-engineered mutant cell models tailored for functional studies and drug testing. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The NRAS (G12A) BAF3 Cell Line enables exploration of NRAS-driven oncogenic pathways, evaluation of RAS pathway inhibitors, and study of IL-3-independent proliferation. It supports drug discovery, mutation-specific research, and mechanistic understanding of NRAS-related cancers.

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