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Transfected Stable Cell Lines

Human NRAS (G12A) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0041C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocyte
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

The NRAS (G12A) BAF3 cell line provides you with a customized tumor research model, aiding drug testing and mechanism understanding to meet your research.

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  • Human NRAS (G12A) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human NRAS (G12A) BAF3 Cell Line

Description

Human NRAS (G12A) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. NRAS (G12A) BAF3 mutant cell line is generated by stable integration of exogenous human NRAS gene harboring the G12A mutation into Ba/F3 host cells using our optimized transduction of lentiviral vectors.
Target
NRAS is a small GTPase that regulates signal transduction through the MAPK and PI3K pathways. The G12A mutation impairs GTP hydrolysis and maintains NRAS in an active, GTP-bound state, contributing to constitutive downstream signaling and oncogenesis. This mutation is recurrent in melanoma and hematologic malignancies. AcceGen offers custom-engineered mutant cell models tailored for functional studies and drug testing. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0041C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • The NRAS (G12A) BAF3 Cell Line enables exploration of NRAS-driven oncogenic pathways, evaluation of RAS pathway inhibitors, and study of IL-3-independent proliferation. It supports drug discovery, mutation-specific research, and mechanistic understanding of NRAS-related cancers.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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