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Transfected Stable Cell Lines

Human NRAS (G12D_Y96D) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0283C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

Human NRAS (G12D_Y96D) BAF3 Cell Line serves as a model for understanding NRAS mutation-driven signaling alterations in hematologic cancers.

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  • Human NRAS (G12D_Y96D) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human NRAS (G12D_Y96D) BAF3 Cell Line

Description

Human NRAS (G12D_Y96D) BAF3 Cell Line is a genetically engineered model derived from murine Ba/F3 cells via stable integration of human NRAS gene with G12D and Y96D point mutations. Lentiviral delivery ensures sustained expression, and edited cells are expanded at low passage (<P20). Validation is performed at gene level using qRT-PCR. Target NRAS mutations at G12D are frequently observed in acute myeloid leukemia and melanoma, promoting constitutive MAPK activation. The additional Y96D mutation modulates effector binding and downstream signaling. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers' research needs.

Species

Human
Cat.No

ABC-X0283C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • This dual-mutant NRAS BAF3 line supports research on NRAS-driven transformation, therapeutic resistance pathways, and screening of selective inhibitors in hematological and skin cancers.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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